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Enevia Health, LLC
30 N Gould Ste N, Sheridan, WY 82801, USA
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The Doctor's Data DNA methylation pathway profile includes a variety of SNPs that influence many aspects of health, including:
SNPs are DNA sequence variations that occur relatively frequently in the general population. They are different from disease mutations, which are very rare. Huntington's disease is an example of a disease mutation: if you inherit the altered gene, the disease will develop.
Certain SNPs may be associated with particular health conditions, but are not known to directly cause disease. Most SNPs affect the structure and function of cellular proteins, enzymes, or receptors.
The identification of SNPs and their impact on health and physiology is an area of ongoing research; the hope is that finding and studying these small variations in DNA will lead to better and more individualized medical interventions. In many cases, the environment (diet, nutrition, exposure to toxic substances, stress) can further modify gene and SNP expression.
SNPs Affecting Detoxification and Methylation they become even more important if a patient has been exposed to toxic substances such as mercury, lead, or bisphenol A (BPA). Lead and BPA inhibit the function of methyltransferases, and mercury inhibits methionine synthase, an enzyme important in homocysteine remethylation. Methylation is an essential step in the detoxification and elimination of arsenic and other xenobiotics. Normal methionine metabolism is a critical component of Phase II detoxification processes; B-12- and folate-dependent transmethylation and B-6-dependent transsulfuration pathways convert homocysteine to cysteine. Cysteine is an important precursor in the biosynthesis of glutathione.
The greatest difficulty in interpreting SNP results is determining the extent to which a DNA genotype is phenotypically expressed. Functional tests, combined with assessment of patient symptoms and responses to intervention, are necessary to assess the influence of known SNPs on the phenotype.
The plasma methylation profile of DDI is one such test; provides a direct assessment of several major metabolites indicating genetic and epigenetic effects. Plasma methylation profiling is a functional follow-up test when identifying SNPs that affect methionine metabolism.
DDI's DNA methylation pathway profiling allows clinicians to screen their patients for a variety of SNPs that can affect the function of important biochemical processes. Identifying SNPs that influence health and disease risk allows clinicians to support their patients with appropriate lifestyle and nutrition changes to maximize health and wellness.
The studied genes in this test are:
ACAT – 1-02
AHCY-19
AHCY-1
AHCY-2
BHMT-1
BHMT-2
BHMT-4
BHMT-8
CBS–A360A
CBS–C699T
CBS–N212N
COMT-61
COMT-H62H
COMT-V158M
MAO A – R297R
MTHFR–3
MTHFR–A1298C
MTHFR–C677T
MTR-A2756G
MTRR-11
MTRR–A66G
MTRR-H595Y
MTRR-K350A
MTRR-R415T
MTRR-S257T
US – D298E
SHMT–C1420T
SUOX-S370S
VDR–Fok1
VDR–Taq1
The results of each gene will be classified as follows:
Minus "-" does not represent any mutation
Plus "+" represents a mutation
"- / -" indicates no mutation
“+/-” indicates that there is a mutation (it is heterozygous)
«+ / +» Indicates that there is a double mutation (it is homozygous)
We will reply as soon as possible.
30 N Gould Ste N, Sheridan, WY 82801, USA
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