More answers from Dr. Boyd Haley and comments from Dr. Kennedy on OSR and AUTISM

By Natalia Marble co-founder of Enevia Health

Dr. Haley goes on to answer more questions about OSR/EMERAMIDE or NBMI, a heavy metal chelator with amazing properties:   

* Can OSR stop purinergic signaling if it is only due to metal chelation effects or does the antioxidant effect of OSR also play a role?

At this time we do not know the mechanism of action of NBMI towards purinergic signalling.

* What do you think about ionic foot baths that remove mercury?

I tried the removed material in ionic foot baths at the request of a mercury poisoned person several years ago. There was no detectable mercury in this material.

* Since Dr. Haley has worked primarily with acute mercury toxicity, I'd like to know what he thinks the prognosis (with Ameramide) would be for severe chronic toxicity.

Due to the antioxidant properties of emeramide that exists in both acute and severe chronic mercury situations, I am convinced that our drug would be effective in both cases. In addition, I tested urine mercury levels in people with chronic mercury before and after treatment with emeramide and it significantly decreased urine mercury levels. Mercury does move around the body a bit and this makes it susceptible to emeramide chelation and detoxification. Furthermore, our tests with radioactive emeramide (14-c-emeramide) showed that our drug enters the cytoplasm of all cells in all tissues where mercury is known to have toxic effects, as both mercury vapor and emeramide are hydrophobic molecules.

* Are there any real success stories of this product when it comes to mercury toxicity and autism? Because I haven't found any.

I copied all the emails about OSR#1 treatment of autistic children in 2008 and 2009. I have them on my computer in electronic format and they are generally very positive. NO adverse effects were noted other than approximately 3 who developed a rash that resolved on discontinuation of treatment. These 3 were able to take OSR after molybdenum supplementation for about 2 weeks.

* Does efficacy depend on the level of toxicity or on the dose? What is the right dose for autistic children?

It definitely depends on the dose and the age and size of the child and how long they've been intoxicated. OSR#1 (also known as emeramide or NBMI) only repairs oxidative stress and heavy metal toxicity. It does not enhance the repair of these tissues and the level of tissue damage must be considered, as the repair of severely damaged neurons in the CNS is difficult to repair. It needs in-depth studies.

* How long should it be used before seeing any clinical improvement in the child?

We have observed that the smaller the child and the shorter the time of the illness, the faster the response and the more positive, especially in intestinal problems. Some positive responses were given within a few days.

* Is there a history of improving autism with OSR?

Yes, this was the likely reason, in my opinion, why the FDA shut down Emeramed. There were many autism blog reports using OSR#1. Among its best effects, the improvement of gastric problems in autistic children was reported.

* Can it be used during pregnancy?

In my opinion yes. OSR was sold as a dietary antioxidant. We have not seen any signs of drug-related adverse effects in all of our human studies.

* OSR seems to make candida worse. My son is allergic to sulfur and I notice that he reacts the same to OSR. How can I get the mercury out of his body if it reacts to the best available chelator?

If you haven't already, I would recommend a two week pre-treatment with a supplement containing molybdenum. The negative response to sulfur-containing compounds such as OSR is due to the accumulation of toxic sulfite due to inactivity of the enzyme sulfite oxidase (converts toxic sulfite, SO3-, to non-toxic sulfate, SO4-2, which is easily excreted in the urine). This enzyme, sulfite oxidase, requires molybdenum as a cofactor to become active in removing toxic sulfite. A study by Dr. Rosemary Waring from England reported that autistic children had levels of toxic sulfites approximately 50 times higher than neurologically normal control children.

* Is there a recommended dose to treat autism with OSR? Does it depend on age or weight? Do we need to increase slowly or can we start with a high dose?

In my opinion, always start low (25-50 mg/day) and slowly work your way up to 200 even 400 mg/day. Parents can observe the child and adjust the dose better than anyone, since all children are different.

* Is there a minimum age to give OSR? Could you give a child 2 years or older what dose would be recommended?

It is safe for all ages. Always watch for a rash as this is the first sign of adverse sulfite production. Take it to 200 mg/day or more.

* Is there a recommended "maintenance" dose after recovery is achieved or can OSR be stopped completely?

I know of parents who were able to reverse autistic symptoms and discontinue treatment without recurrence. These were usually cases of very young autistic children.

* My son is 9 years old and since last month I have been giving him OSR. He reacted well. Can a small dose of 15-25 mg dissolved transdermally in emu oil be given for 1-2 weeks or more?

I don't have any experience, but in my opinion it wouldn't cause any major problem.

* Is there a minimum time interval of less than 22 hours, for example from 16 hours?

No, if your child has gastric problems, I would recommend taking the OSR by mouth.

* Could you please ask Dr. Haley to write a book (like Andy Cutler) on how to chelate mercury and how to detox from chronic mercury poisoning? There are few books and articles, these are several years old, there is nothing new written about chelators.

The FDA prevents me from writing about OSR treatment of autism. I have been conducting the studies required to get emeramide approved for other clinics and other doctors to study. Furthermore, the best important response of using OSR (emeramide) to treat autistic children will be determined after it is approved and used by experienced clinicians and biomedical researchers.

* Would there be any benefit to combining ALA and OSR?

I don't know because Emeramed hasn't tested this.

* Does ALA reach tissues that OSR cannot reach?

No, our radioactive studies show that OSR reaches the cytoplasm and mitochondria of all tissues.

* Does OSR eliminate the need for half-life dosing of ALA?

If you're doing both, I would.

* Thanks for everything. I'd love to understand why even microdoses of OSR can cause adrenal collapse and insomnia in people with chronic mercury toxicity, from a scientific perspective and a potential hypothesis, I'd have to alleviate that.

I don't really know, but I think that the reduction of hydroxyl free radicals would be involved in this situation, since this is the most likely cause of the change in reported insomnia.

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dr kennedy used the OSR in his clinical practice in the US for a few years while the FDA allowed its use. Dr. Kennedy has also offered to answer some of Natalia's questions:

• How to improve oxidative stress due to chronic mercury poisoning?

It makes no difference whether it is consumed with or without food. OSR will not dissolve in water, but can be taken with water. I usually just put it under my tongue some of it will be absorbed and the rest will be swallowed.

My dosage recommendation to eliminate oxidative stress and mercury (Hg) is as follows:

Test first with 100 mg to determine thiol sensitivity. OSR has two thiols. Return2Health has an explanation of thiol sensitivity and a highly recommended thiol self-test.

• If not sensitive to thiol: take 300 mg morning and night for 4 days. Take a day off and then 100 mg every one or two days, depending on how much you have available.
• If thiol sensitive: First supplement molybdenum (Mb) at 100 µg/day for a few days, then try 100 mg. Do this several times and the thiol sensitivity will gradually resolve. Most likely, the reason for the thiol sensitivity is the displacement of Mb by Hg. Once you take in enough OSR, the Hg will be gone and your body will replace the missing Mb.

My prediction is that 90 % of mercury and most of the oxidative stress will bind and be excreted within 72 hours. Radioactive studies in animals prove it. The rest will disappear completely in 72 days. OSR removes mercury very quickly, but some of the other metals take longer because they may not be near the circulating blood, such as lead in cortical bone. You have to remodel the bone to expose that sequestered lead to the OSR. That is why I recommend a prolonged treatment. Works better.

Avoid further exposures and do not eat fish, do not put mercury/silver fillings in your teeth. If you intend to polish existing mercury/silver dental fillings, i.e. during a dental cleaning or removal, take 300 mg 2-4 hours before your appointment.

Sulfur sensitivity

The only problem I know of is thiol sensitivity. OSR#1 has two thiols. This is how it instantly attracts mercury by presenting beautiful loose thiols. If you have been poisoned with mercury for a long time, your ability to digest sulfur and metabolize thiols may be compromised by mercury displacing molybdenum (Mb) from the enzyme molybdopterin. Sulfite sensitivity is actually a rare symptom of mercury poisoning, but OSR#1 has helped people recover from this symptom. Not all people poisoned by mercury are intolerant to sulfur. FYI, none of the gold miners had an intolerance to sulfite, so it's obviously highly variable.

• Sulfite/Sulfur Sensitivity

The only problem I know of is thiol sensitivity. OSR#1 has two thiols. This is how it instantly attracts mercury by presenting loose thiols. If you have been intoxicated with mercury for a long time, your ability to digest sulfur and metabolize thiols may be compromised by mercury displacing molybdenum (Mb) from the enzyme molybdopterin. Sulfite sensitivity is actually a rare symptom of mercury poisoning, but OSR#1 has helped people recover from this symptom, although not all mercury poisoned people are sulfur intolerant.

• Why is this happening?

Mercury displaces essential minerals, especially iron, copper, and molybdenum. You'll notice sulfite intolerance with exposure to sulfites in wines or perhaps monosodium glutamate in foods or condiments. OSR#1 contains sulfur in a precise configuration because that is the only element that will irreversibly bind to mercury. Sulphite/sulfur intolerance can be expressed as itching or headache. I recommend that you start by taking a small test dose of about 50 mg to determine if you tolerate the compound and then 300 mg/day (short white slightly rounded spoon). Since the OSR#1 remains active for about 2 days after the first week. You can try to take it every other day to preserve it.

If you determine that you are sulfur intolerant, don't despair, as OSR#1 can reverse this condition over time when supplemented with 100 micrograms of molybdenum. After a few days, you may be able to use OSR#1 without difficulty, as OSR will remove the mercury from the molybdopterin enzyme and supplementation will allow normal sulfur processing to resume. This symptom is likely to resolve. 

• Why does this happen?

Mercury displaces essential minerals especially iron, copper, and molybdenum. You would notice this when exposed to sulfites from wines or perhaps MSG in foods or condiments. OSR#1 does contain sulfur in a precise configuration because that is the only element that will irreversibly bind mercury. Sulfur intolerance may be expressed as itching or headache. I recommend you begin by taking a small trial dose of about 50 mg to determine if you tolerate the compound then 300 mg/day (Short white spoon slightly rounded). Since OSR#1 stays active for about 2 days after the first week. You can try to take it every other day to keep it. 

If you determine you are sulfur intolerant do not despair as OSR#1 over time can reverse this condition if you supplement with 100 micrograms of molybdenum. After a few days you may be able to use OSR#1 without difficulty as OSR will pull the mercury off the enzyme molybdopterin and your supplementation will allow your normal processing of sulfur to recover. This symptom will likely resolve.

• What about amalgam fillings?

Most mercury-poisoned people are injured by mercury/silver amalgam fillings. If you have these fillings, they must be removed safely. No dental school teaches this, so ordinary dentists can and have made this condition worse by carelessly removing mercury fillings. For your protection, I recommend that you take OSR#1 at least 2 hours before dental work involving mercury.

Regarding gadolinium chelation, we have not done clinical trials, but we have an understanding of the behavior of Gd, and it should be attracted by NBMI. In addition, there are several reports of NBMI indicating great benefit in reducing pain.

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