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Enevia Health, LLC
30 N Gould Ste N, Sheridan, WY 82801, USA
FRAT ® (Folate Receptor Antibody Test)
It measures the presence of antibodies that interact (block or bind) with folate receptor activity A (FRA A). FRAAs appear to have a high prevalence in children with ASD, so it is recommended that testing be considered in all people with ASD.
The FRAT test analyzes the Folate Receptor Antibodies which may be responsible for reducing the transport of folate (an essential B vitamin) and its active metabolites (most notably 5-MTHF) across barriers to the brain, placenta and ovaries, thus contributing to various neurological deficits such as autism, deficiency of brain folate, neural tube defects, and schizophrenia, among other conditions.
Iliad Neurosciences is the world leader in research on folate receptor antibodies and their implications in neurodevelopmental disorders.
A study of folinic acid and folate receptor antibodies in a randomized double-blind placebo-controlled trial.
What is the relationship between autism and folate?
There is a disorder called Cerebral Folate Deficiency (CFD) which in many cases have symptoms compatible with autism, such as developmental regression, speech problems, seizures, agitation and insomnia, hypotonia, psychomotor retardation, epilepsy, gait disorders, ataxia...
CFD is caused, in some cases, by folate receptor alpha antibodies (FRAAs) that block folate from entering the brain. CFD in many cases can be treated with folinic acid. When folinic acid is administered, active metabolic levels of folate increase and clinical improvements occur in these patients.
Folinic acid is a type of folic acid that can enter the brain through a different channel than the more common folic acids.
The doctor. Richard Frye noted a very high prevalence of Folate Receptor Antibodies (FRAA) in the blood of children with ASD, and that some had low levels of folate in their central nervous system, similar to children with CFD.
Dr. Frye and his group published the results of a multi-year study showing that folinic acid improves speech, language, and other symptoms in children with autism (improvement in verbal communication and other behaviors such as life skills daily, irritability, stereotyped behavior and hyperactivity).
Link to the study: https://www.nature.com/articles/mp2011175
The study also showed that the FRAA biomarker could help predict who will respond to folinic acid treatment.
You have to contact the collaborating entity you want from your country:
Argentina:
Laboratory IICT LABS
Autism Bioapproach Foundation
Ecuador:
Doctor Oscar Castro
Peru:
GFG Laboratory
Uruguay:
Doctor Antonella Fanetti
Purchase process: contact the collaborating laboratory to manage the test.
ARGENTINA
Laboratory IICT LABS
1220 Miter Street
S2000BHX
ROSARY BEADS
SANTA FE, ARGENTINA.
+543414484517
www.iictlabs.com
iict@iictlabs.com
CUIT: 33-70874216-9
Contact person:
Coordinator Franco Pongelli
+543413201729
fpongelli@iictlabs.com
PERU
GFG Laboratory
El Sauzal Passage. 105 Urb. Los Sauces
(Alt. block 8 av. 8 av. Villarán)
Surquillo, Lime
Peru
+51 989 692 828
Contact person:
Coordinator of Enevia Health in Peru Giovanna Bejerano
+51 983 514 369
Address of attention: Av. Benavides 2426 office 202 Miraflores. Lima 15048
Opening hours: Wednesdays 10:30 am to 12:30 pm.
URUGUAY
Doctor Antonella Fanetti De La Hoz
Office address:
Contact person:
Doctor Antonella Fanetti De La Hoz
Contact number: +598 99 728 557
Mail: antonellafanetti@gmail.com
Hours: 9:00 AM to 3:00 PM
ECUADOR
Doctor Oscar Castro
Contact person:
Enevia Health Coordinator in Ecuador: Doctor Oscar Castro
Mail: nutraautism@gmail.com
Schedule: 09:00 to 20:00
ARGENTINA
Autism Bioapproach Foundation:
Department 1ºC
Juan Agustin Garcia 2780
(1419) Villa, Santa Rita.
CABA, Argentina
Reports: autismobio@gmail.com
+54 11 6825-8726
Studies: bioabordajesdelautismo@hotmail.com
+54 11 5062-0709
Contact person:
adriana peralta
Biomedical nutritional advice
Master of Disability
President of the Autism Bioapproach Foundation.
In PDF-1 you can access information on the scientific basis of FRAT, in PDF-2 a list of questions and answers and in PDF-3 you will find more information on the improvement of folinic acid and communication.
We will reply as soon as possible.
30 N Gould Ste N, Sheridan, WY 82801, USA
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