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Enevia Health, LLC
30 N Gould Ste N, Sheridan, WY 82801, USA
FRAT ® (Folate Receptor Antibody Test)
It measures the presence of antibodies that interact (block or bind) with folate receptor activity A (FRA A). FRAAs appear to have a high prevalence in children with ASD, so it is recommended that testing be considered in all people with ASD.
The FRAT test analyzes the Folate Receptor Antibodies which may be responsible for reducing the transport of folate (an essential B vitamin) and its active metabolites (most notably 5-MTHF) across barriers to the brain, placenta and ovaries, thus contributing to various neurological deficits such as autism, deficiency of brain folate, neural tube defects, and schizophrenia, among other conditions.
Iliad Neurosciences is the world leader in research on folate receptor antibodies and their implications in neurodevelopmental disorders.
A study of folinic acid and folate receptor antibodies in a randomized double-blind placebo-controlled trial.
What is the relationship between autism and folate?
There is a disorder called Cerebral Folate Deficiency (CFD) which in many cases have symptoms compatible with autism, such as developmental regression, speech problems, seizures, agitation and insomnia, hypotonia, psychomotor retardation, epilepsy, gait disorders, ataxia...
CFD is caused, in some cases, by folate receptor alpha antibodies (FRAAs) that block folate from entering the brain. CFD in many cases can be treated with folinic acid. When folinic acid is administered, active metabolic levels of folate increase and clinical improvements occur in these patients.
Folinic acid is a type of folic acid that can enter the brain through a different channel than the more common folic acids.
The doctor. Richard Frye noted a very high prevalence of Folate Receptor Antibodies (FRAA) in the blood of children with ASD, and that some had low levels of folate in their central nervous system, similar to children with CFD.
Dr. Frye and his group published the results of a multi-year study showing that folinic acid improves speech, language, and other symptoms in children with autism (improvement in verbal communication and other behaviors such as life skills daily, irritability, stereotyped behavior and hyperactivity).
Link to the study: https://www.nature.com/articles/mp2011175
The study also showed that the FRAA biomarker could help predict who will respond to folinic acid treatment.
GFG Laboratory
Purchase process: contact the collaborating laboratory to manage the test.
PERU
GFG Laboratory
El Sauzal Passage. 105 Urb. Los Sauces
(Alt. block 8 av. 8 av. Villarán)
Surquillo, Lime
Peru
+51 989 692 828
Contact person:
Coordinator of Enevia Health in Peru Giovanna Bejerano
+51 983 514 369
Address of attention: Av. Benavides 2426 office 202 Miraflores. Lima 15048
Opening hours: Wednesdays 10:30 am to 12:30 pm.
In PDF-1 you can access information on the scientific basis of FRAT, in PDF-2 a list of questions and answers and in PDF-3 you will find more information on the improvement of folinic acid and communication.
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30 N Gould Ste N, Sheridan, WY 82801, USA
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