OAT Organic Acid Test – Diagnostic Solutions – Latin America

Urine organic acid testing can help doctors identify dysfunctions in key metabolic pathways. Dysfunctional metabolic pathways can negatively impact mood, energy production, and overall health, while providing insights into nutrient insufficiency, dietary composition, toxic exposures, and microbial metabolism.

The personalized information generated in the organic acid profile test report can establish a patient's baseline status and help practitioners personalize protocols.

Evaluation of organic acids

What are the benefits of organic acid testing?

Organic acid tests provide information on how well patients function metabolically. Practitioners can use insights from organic acid profiling to personalize protocols that help patients improve dysfunctional pathways that may be contributing to current or future disease states.

The benefits of organic acid testing include:

• Organic acids are efficiently excreted through the kidneys as end products of metabolism. Assessment of organic acids in urine is a preferred and easy-to-collect test option.
• Organic acids are produced endogenously during normal cellular metabolism and require vitamins, minerals, and other dietary-derived compounds as processing cofactors. Organic acid testing provides professionals with essential clues for targeted supplementation.
• Catabolic products of essential amino acids in urine may help identify the flow of dysfunctional metabolic pathways. Amino acid breakdown products can help you better understand:
  • Nutrient cofactor needs
  • methylation
  • Catecholamine turnover
  • glutathione status
  • Inflammation level
• The organic acid profile assesses imbalances in the organic acid intermediates of the Krebs cycle. Understanding imbalances in the Krebs cycle can help identify the location of poor flow and potential pathway impacts.
• The organic acid profile helps identify impacts on stress and mood disorders by providing information on neurotransmitter turnover and cortisol levels.
• Intestinal bacteria produce organic acids during their metabolic processing. Identification of these unique compounds may indicate possible gut microbiome imbalances.

Personalized medicine

Organic acid profile analytes are listed together by pathway with associated enzymes and nutrient cofactors. Personalized treatment recommendations, based on the findings, are conveniently summarized in the test report.

The report cover provides a quick graphical interpretation that professionals can use to easily review results with patients. Ask the organic acid profile sample report for more details.

The organic acid profile is categorized according to the following key functional areas of patient health:

1. Metabolic processing
2. Amino acid and protein metabolism
3. Nutrition
4. Stress and mood
5. Microbial metabolites
6. Toxic impacts

Who can benefit from the organic acid profile?

Organic acid profiling helps professionals quickly identify dysfunctions that have been associated with a wide range of conditions. The test report has been designed to help professionals establish a patient baseline and identify possible core problems in those with health problems.

Research in metabolomics has evaluated the following conditions associated with organic acid testing:

• Dysmetabolism, prediabetes and diabetes.
• Weight changes and obesity.
• Fatigue
• Athletic performance
• Poor immune function
• Depression and anxiety
• Gastrointestinal microbial activity
• Kidney and liver dysfunction.

Methodology

• MS/MS : Newer tests result in significant increases in sensitivity and specificity, and greater reproducibility.

Sample requirements

• Urine: first morning urination